SMO gene

smoothened, frizzled class receptor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

From UniProt:

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

From NCBI Gene:

  • Basal cell carcinoma, multiple
  • Craniofacial malformations, asymmetric, with polysyndactyly and abnormal skin and gut development

Cytogenetic Location: 7q32.1, which is the long (q) arm of chromosome 7 at position 32.1

Molecular Location: base pairs 129,188,872 to 129,213,548 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q32.1, which is the long (q) arm of chromosome 7 at position 32.1
  • CRJS
  • FZD11
  • Gx
  • SMOH