SLC6A2 gene

solute carrier family 6 member 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

From UniProt:

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

From NCBI Gene:

  • Orthostatic intolerance

From UniProt:

Orthostatic intolerance (OI): Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. [MIM:604715]

Cytogenetic Location: 16q12.2, which is the long (q) arm of chromosome 16 at position 12.2

Molecular Location: base pairs 55,655,604 to 55,706,192 on chromosome 16 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 16q12.2, which is the long (q) arm of chromosome 16 at position 12.2
  • NAT1
  • NET
  • NET1
  • SLC6A5