SLC30A8 gene

solute carrier family 30 member 8

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

From UniProt:

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.

Cytogenetic Location: 8q24.11, which is the long (q) arm of chromosome 8 at position 24.11

Molecular Location: base pairs 116,950,273 to 117,176,714 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8q24.11, which is the long (q) arm of chromosome 8 at position 24.11
  • ZnT-8
  • ZNT8