SLC26A3

solute carrier family 26 member 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]

From UniProt:

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

From NCBI Gene:

  • Congenital secretory diarrhea, chloride type

From UniProt:

Diarrhea 1, secretory chloride, congenital (DIAR1): A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. [MIM:214700]

Cytogenetic Location: 7q31, which is the long (q) arm of chromosome 7 at position 31

Molecular Location: base pairs 107,765,467 to 107,803,233 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q31, which is the long (q) arm of chromosome 7 at position 31
  • CLD
  • DRA