SLC14A1 gene

solute carrier family 14 member 1 (Kidd blood group)

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]

From UniProt:

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.

Cytogenetic Location: 18q12.3, which is the long (q) arm of chromosome 18 at position 12.3

Molecular Location: base pairs 45,724,123 to 45,752,520 on chromosome 18 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 18q12.3, which is the long (q) arm of chromosome 18 at position 12.3
  • HsT1341
  • HUT11
  • JK
  • RACH1
  • RACH2
  • UT-B1
  • UT1
  • UTE