SIM1 gene

single-minded family bHLH transcription factor 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq, Jul 2008]

From UniProt:

Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.

Cytogenetic Location: 6q16.3, which is the long (q) arm of chromosome 6 at position 16.3

Molecular Location: base pairs 100,385,009 to 100,464,929 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6q16.3, which is the long (q) arm of chromosome 6 at position 16.3
  • bHLHe14