SFTPA2 gene

surfactant protein A2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]

From UniProt:

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Idiopathic fibrosing alveolitis, chronic form

From UniProt:

Pulmonary fibrosis, idiopathic (IPF): A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. [MIM:178500]

Cytogenetic Location: 10q22.3, which is the long (q) arm of chromosome 10 at position 22.3

Molecular Location: base pairs 79,555,852 to 79,560,461 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q22.3, which is the long (q) arm of chromosome 10 at position 22.3
  • COLEC5
  • PSAP
  • PSP-A
  • PSPA
  • SFTP1
  • SP-2A
  • SP-A
  • SPA2