SFRP4 gene

secreted frizzled related protein 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

From UniProt:

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Pyle metaphyseal dysplasia

Cytogenetic Location: 7p14.1, which is the short (p) arm of chromosome 7 at position 14.1

Molecular Location: base pairs 37,905,932 to 37,916,923 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7p14.1, which is the short (p) arm of chromosome 7 at position 14.1
  • FRP-4
  • FRPHE
  • PYL
  • sFRP-4