SECISBP2 gene

SECIS binding protein 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

From UniProt:

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

From NCBI Gene:

  • Thyroid hormone metabolism, abnormal

From UniProt:

Abnormal thyroid hormone metabolism (ATHYHM): A disorder associated with a reduction in type II iodothyronine deiodinase activity. [MIM:609698]

Cytogenetic Location: 9q22.2, which is the long (q) arm of chromosome 9 at position 22.2

Molecular Location: base pairs 89,318,473 to 89,367,117 on chromosome 9 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 9q22.2, which is the long (q) arm of chromosome 9 at position 22.2