SECISBP2 gene

SECIS binding protein 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

From UniProt:

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

From NCBI Gene:

  • Thyroid hormone metabolism, abnormal

From UniProt:

Abnormal thyroid hormone metabolism (ATHYHM): A disorder associated with a reduction in type II iodothyronine deiodinase activity. [MIM:609698]

Cytogenetic Location: 9q22.2, which is the long (q) arm of chromosome 9 at position 22.2

Molecular Location: base pairs 89,318,473 to 89,367,117 on chromosome 9 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 9q22.2, which is the long (q) arm of chromosome 9 at position 22.2