SEC63 gene

SEC63 homolog, protein translocation regulator

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

From UniProt:

Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

From NCBI Gene:

  • Congenital cystic disease of liver
  • Polycystic liver disease 2

From UniProt:

Polycystic liver disease (PCLD): A hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. [MIM:174050]

Cytogenetic Location: 6q21, which is the long (q) arm of chromosome 6 at position 21

Molecular Location: base pairs 107,867,756 to 107,958,278 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6q21, which is the long (q) arm of chromosome 6 at position 21
  • DNAJC23
  • ERdj2
  • PCLD2
  • PRO2507
  • SEC63L