SEC63 gene

SEC63 homolog, protein translocation regulator

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

From UniProt:

Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia.

From NCBI Gene:

  • Polycystic liver disease 2

From UniProt:

Polycystic liver disease 2 with or without kidney cysts (PCLD2): An autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. A subset of patients may develop kidney cysts that usually do not result in clinically significant renal disease. [MIM:617004]

Cytogenetic Location: 6q21, which is the long (q) arm of chromosome 6 at position 21

Molecular Location: base pairs 107,867,756 to 107,958,278 on chromosome 6 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 6q21, which is the long (q) arm of chromosome 6 at position 21
  • DNAJC23
  • ERdj2
  • PCLD2
  • PRO2507
  • SEC63L