SEC61A1 gene

Sec61 translocon alpha 1 subunit

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

From UniProt:

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.

From NCBI Gene:

  • Hyperuricemic nephropathy, familial juvenile, 4

Cytogenetic Location: 3q21.3, which is the long (q) arm of chromosome 3 at position 21.3

Molecular Location: base pairs 128,052,369 to 128,071,683 on chromosome 3 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 3q21.3, which is the long (q) arm of chromosome 3 at position 21.3
  • HNFJ4
  • HSEC61
  • SEC61
  • SEC61A