SEC31A gene

SEC31 homolog A, COPII coat complex component

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

From UniProt:

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).

From NCBI Gene:


From UniProt:

A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.

Cytogenetic Location: 4q21.22, which is the long (q) arm of chromosome 4 at position 21.22

Molecular Location: base pairs 82,818,509 to 82,900,571 on chromosome 4 (Homo sapiens Updated Annotation Release 109.20200228, GRCh38.p13) (NCBI)

Cytogenetic Location: 4q21.22, which is the long (q) arm of chromosome 4 at position 21.22
  • ABP125
  • ABP130
  • HSPC275
  • HSPC334
  • SEC31L1