SAA2 gene

serum amyloid A2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. [provided by RefSeq, Jul 2020]

From UniProt:

Major acute phase reactant.

From UniProt:

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA2 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

Cytogenetic Location: 11p15.1, which is the short (p) arm of chromosome 11 at position 15.1

Molecular Location: base pairs 18,238,236 to 18,248,668 on chromosome 11 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 11p15.1, which is the short (p) arm of chromosome 11 at position 15.1
  • SAA
  • SAA1