RHCE gene

Rh blood group CcEe antigens

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Aug 2016]

From UniProt:

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

From NCBI Gene:


From UniProt:

Rh-null, amorph type (RHNA): An autosomal recessive condition characterized by red blood cells that lack all Rh antigens, have increased osmotic fragility, diminished lifespan, and show changes in morphology resulting in stomatocytosis. Rh-null individuals have mild to moderate hemolytic anemia. They are at risk of having adverse reactions in response to transfusion or pregnancy, because they may produce antibodies against several of the Rh antigens. [MIM:617970]

Cytogenetic Location: 1p36.11, which is the short (p) arm of chromosome 1 at position 36.11

Molecular Location: base pairs 25,360,659 to 25,430,193 on chromosome 1 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 1p36.11, which is the short (p) arm of chromosome 1 at position 36.11
  • CD240CE
  • RH
  • Rh4
  • RH30A
  • RHC
  • RHCe(152N)
  • RHE
  • RhIVb(J)
  • RHNA
  • RHPI
  • RhVI
  • RhVIII