REC114 gene

REC114 meiotic recombination protein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is orthologous to the mouse meiotic recombination protein REC114, which is involved in DNA double-strand break formation during meiosis. The encoded protein is conserved in most eukaryotes and was first discovered and characterized in yeast. [provided by RefSeq, Feb 2017]

From UniProt:

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.

Cytogenetic Location: 15q24.1, which is the long (q) arm of chromosome 15 at position 24.1

Molecular Location: base pairs 73,443,164 to 73,560,013 on chromosome 15 (Homo sapiens Updated Annotation Release 109.20190607, GRCh38.p13) (NCBI)

Cytogenetic Location: 15q24.1, which is the long (q) arm of chromosome 15 at position 24.1
  • C15orf60
  • CT147