RCAN1

regulator of calcineurin 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

From UniProt:

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

Cytogenetic Location: 21q22.12, which is the long (q) arm of chromosome 21 at position 22.12

Molecular Location: base pairs 34,516,442 to 34,615,142 on chromosome 21 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 21q22.12, which is the long (q) arm of chromosome 21 at position 22.12
  • ADAPT78
  • CSP1
  • DSC1
  • DSCR1
  • MCIP1
  • RCN1