RARS gene

arginyl-tRNA synthetase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]

From UniProt:

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).

From NCBI Gene:

  • Leukodystrophy, hypomyelinating, 9

From UniProt:

Leukodystrophy, hypomyelinating, 9 (HLD9): An autosomal recessive neurodegenerative disorder characterized by delayed psychomotor development, severe spasticity, nystagmus, and ataxia associated with diffuse hypomyelination apparent on brain MRI. [MIM:616140]

Cytogenetic Location: 5q34, which is the long (q) arm of chromosome 5 at position 34

Molecular Location: base pairs 168,486,458 to 168,519,306 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q34, which is the long (q) arm of chromosome 5 at position 34
  • ArgRS
  • DALRD1
  • HLD9