RAET1L gene

retinoic acid early transcript 1L

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]

From UniProt:

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Cytogenetic Location: 6q25.1, which is the long (q) arm of chromosome 6 at position 25.1

Molecular Location: base pairs 150,018,334 to 150,025,596 on chromosome 6 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 6q25.1, which is the long (q) arm of chromosome 6 at position 25.1