PTPRN2 gene

protein tyrosine phosphatase, receptor type N2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

From UniProt:

Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

From UniProt:

Autoantigen in insulin-dependent diabetes mellitus (IDDM).

Cytogenetic Location: 7q36, which is the long (q) arm of chromosome 7 at position 36

Molecular Location: base pairs 157,539,052 to 158,587,802 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q36, which is the long (q) arm of chromosome 7 at position 36
  • IA-2beta
  • IAR
  • ICAAR
  • PTPRP
  • R-PTP-N2