PTPN3 gene

protein tyrosine phosphatase, non-receptor type 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

From UniProt:

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Cytogenetic Location: 9q31, which is the long (q) arm of chromosome 9 at position 31

Molecular Location: base pairs 109,375,694 to 109,538,395 on chromosome 9 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 9q31, which is the long (q) arm of chromosome 9 at position 31
  • PTP-H1
  • PTPH1