PTGIS gene

prostaglandin I2 synthase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

From UniProt:

Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

From NCBI Gene:

  • Essential hypertension

From UniProt:

Essential hypertension (EHT): A condition in which blood pressure is consistently higher than normal with no identifiable cause. [MIM:145500]

Cytogenetic Location: 20q13.13, which is the long (q) arm of chromosome 20 at position 13.13

Molecular Location: base pairs 49,503,874 to 49,568,170 on chromosome 20 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 20q13.13, which is the long (q) arm of chromosome 20 at position 13.13
  • CYP8
  • CYP8A1
  • PGIS
  • PTGI