PTGDR gene

prostaglandin D2 receptor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

From UniProt:

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate.

From NCBI Gene:

  • Asthma-related traits, susceptibility to, 1

From UniProt:

Asthma-related traits 1 (ASRT1): Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. [MIM:607277]

Cytogenetic Location: 14q22.1, which is the long (q) arm of chromosome 14 at position 22.1

Molecular Location: base pairs 52,267,256 to 52,280,914 on chromosome 14 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 14q22.1, which is the long (q) arm of chromosome 14 at position 22.1
  • AS1
  • ASRT1
  • DP
  • DP1
  • PTGDR1