PRCC gene

papillary renal cell carcinoma (translocation-associated)

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

From UniProt:

May regulate cell cycle progression through interaction with MAD2L2.

From NCBI Gene:

  • Renal cell carcinoma, papillary, 1

From UniProt:

A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3.

Cytogenetic Location: 1q23.1, which is the long (q) arm of chromosome 1 at position 23.1

Molecular Location: base pairs 156,767,482 to 156,800,819 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q23.1, which is the long (q) arm of chromosome 1 at position 23.1
  • RCCP1
  • TPRC