PPP2R1B gene

protein phosphatase 2 scaffold subunit Abeta

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

From UniProt:

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.

Cytogenetic Location: 11q23.2, which is the long (q) arm of chromosome 11 at position 23.2

Molecular Location: base pairs 111,694,569 to 111,766,445 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q23.2, which is the long (q) arm of chromosome 11 at position 23.2
  • PP2A-Abeta
  • PR65B