PPP2R1A gene

protein phosphatase 2 scaffold subunit Aalpha

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

From UniProt:

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.

From NCBI Gene:

  • Mental retardation, autosomal dominant 36

From UniProt:

Mental retardation, autosomal dominant 36 (MRD36): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. [MIM:616362]

Cytogenetic Location: 19q13.41, which is the long (q) arm of chromosome 19 at position 13.41

Molecular Location: base pairs 52,189,802 to 52,226,425 on chromosome 19 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 19q13.41, which is the long (q) arm of chromosome 19 at position 13.41
  • MRD36
  • PP2A-Aalpha
  • PP2AAALPHA
  • PR65A