PPIB gene

peptidylprolyl isomerase B

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

From UniProt:

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

From NCBI Gene:

  • Osteogenesis imperfecta type 9

From UniProt:

Osteogenesis imperfecta 9 (OI9): A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. [MIM:259440]

Cytogenetic Location: 15q21-q22, which is the long (q) arm of chromosome 15 between positions 21 and 22

Molecular Location: base pairs 64,155,815 to 64,163,155 on chromosome 15 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 15q21-q22, which is the long (q) arm of chromosome 15 between positions 21 and 22
  • CYP-S1
  • CYPB
  • HEL-S-39
  • OI9
  • SCYLP