POU6F2 gene

POU class 6 homeobox 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

From UniProt:

Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.

From NCBI Gene:

  • Wilms tumor and radial bilateral aplasia

From UniProt:

Hereditary susceptibility to Wilms tumor 5 (WT5): Pediatric malignancy of kidney and one of the most common solid cancers in childhood. [MIM:601583]

Cytogenetic Location: 7p14.1, which is the short (p) arm of chromosome 7 at position 14.1

Molecular Location: base pairs 38,977,878 to 39,468,601 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7p14.1, which is the short (p) arm of chromosome 7 at position 14.1
  • RPF-1
  • WT5
  • WTSL