POU4F3 gene

POU class 4 homeobox 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]

From UniProt:

Transcription factor. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Deafness, autosomal dominant 15

From UniProt:

Deafness, autosomal dominant, 15 (DFNA15): A form of non-syndromic hearing loss with variable phenotype in terms of age at onset, levels of progression, and shape of audiograms. [MIM:602459]

Cytogenetic Location: 5q32, which is the long (q) arm of chromosome 5 at position 32

Molecular Location: base pairs 146,339,024 to 146,340,520 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q32, which is the long (q) arm of chromosome 5 at position 32
  • BRN3C
  • DFNA15
  • DFNA42
  • DFNA52