PON1 gene

paraoxonase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]

From UniProt:

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

From NCBI Gene:

  • Microvascular complications of diabetes 5

From UniProt:

Microvascular complications of diabetes 5 (MVCD5): Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. [MIM:612633]

Cytogenetic Location: 7q21.3, which is the long (q) arm of chromosome 7 at position 21.3

Molecular Location: base pairs 95,298,357 to 95,324,572 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q21.3, which is the long (q) arm of chromosome 7 at position 21.3
  • ESA
  • MVCD5
  • PON