POLA1 gene

DNA polymerase alpha 1, catalytic subunit

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]

From UniProt:

Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.

From NCBI Gene:

  • Pigmentary disorder, reticulate, with systemic manifestations, X-linked
  • N syndrome

Cytogenetic Location: Xp22.11-p21.3, which is the short (p) arm of the X chromosome between positions 22.11 and 21.3

Molecular Location: base pairs 24,693,833 to 24,996,986 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Xp22.11-p21.3, which is the short (p) arm of the X chromosome between positions 22.11 and 21.3
  • NSX
  • p180
  • POLA