PNOC gene

prepronociceptin

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

From UniProt:

Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.

Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.

Orphanin FQ2: Has potent analgesic activity.

Cytogenetic Location: 8p21.1, which is the short (p) arm of chromosome 8 at position 21.1

Molecular Location: base pairs 28,316,979 to 28,343,355 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8p21.1, which is the short (p) arm of chromosome 8 at position 21.1
  • N/OFQ
  • NOP
  • OFQ
  • ppN/OFQ
  • PPNOC