PNLIP gene

pancreatic lipase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016]

From NCBI Gene:

  • Pancreatic lipase deficiency

From UniProt:

Pancreatic lipase deficiency (PNLIPD): An autosomal recessive disorder characterized by exocrine pancreatic failure. Clinical findings include oily/greasy stools from infancy or early childhood, absence of discernible pancreatic disease, and significantly decreased pancreatic lipolytic activity. [MIM:614338]

Cytogenetic Location: 10q25.3, which is the long (q) arm of chromosome 10 at position 25.3

Molecular Location: base pairs 116,545,916 to 116,567,855 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q25.3, which is the long (q) arm of chromosome 10 at position 25.3
  • PL
  • PNLIPD
  • PTL