PIGC gene

phosphatidylinositol glycan anchor biosynthesis class C

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]

From UniProt:

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

From NCBI Gene:

  • GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 16

Cytogenetic Location: 1q24.3, which is the long (q) arm of chromosome 1 at position 24.3

Molecular Location: base pairs 172,441,457 to 172,444,090 on chromosome 1 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 1q24.3, which is the long (q) arm of chromosome 1 at position 24.3
  • GPI2
  • GPIBD16
  • MRT62