PHB gene

prohibitin

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

From UniProt:

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Cytogenetic Location: 17q21, which is the long (q) arm of chromosome 17 at position 21

Molecular Location: base pairs 49,404,048 to 49,414,905 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17q21, which is the long (q) arm of chromosome 17 at position 21
  • HEL-215
  • HEL-S-54e
  • PHB1