PDCD1 gene

programmed cell death 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

From UniProt:

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.

Covered on Genetics Home Reference:

From UniProt:

Systemic lupus erythematosus 2 (SLEB2): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [MIM:605218]

Cytogenetic Location: 2q37.3, which is the long (q) arm of chromosome 2 at position 37.3

Molecular Location: base pairs 241,849,881 to 241,858,908 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q37.3, which is the long (q) arm of chromosome 2 at position 37.3
  • CD279
  • hPD-1
  • hPD-l
  • hSLE1
  • PD-1
  • PD1
  • SLEB2