PCDH11Y gene

protocadherin 11 Y-linked

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

From UniProt:

Potential calcium-dependent cell-adhesion protein.

From UniProt:

A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.

Cytogenetic Location: Yp11.2, which is the short (p) arm of the Y chromosome at position 11.2

Molecular Location: base pairs 5,000,044 to 5,742,228 on the Y chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Yp11.2, which is the short (p) arm of the Y chromosome at position 11.2
  • PCDH-PC
  • PCDH22
  • PCDHX
  • PCDHY