PATZ1 gene

POZ/BTB and AT hook containing zinc finger 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Transcriptional repressor.

From UniProt:

A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.

Cytogenetic Location: 22q12.2, which is the long (q) arm of chromosome 22 at position 12.2

Molecular Location: base pairs 31,325,804 to 31,346,346 on chromosome 22 (Homo sapiens Updated Annotation Release 109.20190607, GRCh38.p13) (NCBI)

Cytogenetic Location: 22q12.2, which is the long (q) arm of chromosome 22 at position 12.2
  • dJ400N23
  • MAZR
  • PATZ
  • RIAZ
  • ZBTB19
  • ZNF278
  • ZSG