OVOL2 gene

ovo like zinc finger 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

From UniProt:

Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.

From NCBI Gene:

  • Posterior polymorphous corneal dystrophy 1

Cytogenetic Location: 20p11.23, which is the short (p) arm of chromosome 20 at position 11.23

Molecular Location: base pairs 18,024,152 to 18,059,188 on chromosome 20 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 20p11.23, which is the short (p) arm of chromosome 20 at position 11.23
  • EUROIMAGE566589
  • PPCD1
  • ZNF339