OTOA gene

otoancorin

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

From UniProt:

May act as an adhesion molecule.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Deafness, autosomal recessive 22

From UniProt:

Deafness, autosomal recessive, 22 (DFNB22): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [MIM:607039]

Cytogenetic Location: 16p12.2, which is the short (p) arm of chromosome 16 at position 12.2

Molecular Location: base pairs 21,663,857 to 21,771,468 on chromosome 16 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 16p12.2, which is the short (p) arm of chromosome 16 at position 12.2
  • CT108
  • DFNB22