OPRD1 gene

opioid receptor delta 1

The information on this page was automatically extracted from online scientific databases.

From UniProt:

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Cytogenetic Location: 1p35.3, which is the short (p) arm of chromosome 1 at position 35.3

Molecular Location: base pairs 28,812,142 to 28,863,696 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p35.3, which is the short (p) arm of chromosome 1 at position 35.3