OPCML gene

opioid binding protein/cell adhesion molecule like

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

From UniProt:

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Neoplasm of ovary

From UniProt:

Ovarian cancer (OC): The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. [MIM:167000]

Cytogenetic Location: 11q25, which is the long (q) arm of chromosome 11 at position 25

Molecular Location: base pairs 132,403,361 to 133,532,983 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q25, which is the long (q) arm of chromosome 11 at position 25
  • IGLON1
  • OBCAM
  • OPCM