OLIG2 gene

oligodendrocyte lineage transcription factor 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

From UniProt:

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.

Covered on Genetics Home Reference:

From UniProt:

A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Cytogenetic Location: 21q22.11, which is the long (q) arm of chromosome 21 at position 22.11

Molecular Location: base pairs 33,025,908 to 33,029,196 on chromosome 21 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 21q22.11, which is the long (q) arm of chromosome 21 at position 22.11
  • BHLHB1
  • bHLHe19
  • OLIGO2
  • PRKCBP2
  • RACK17