NXF5 gene

nuclear RNA export factor 5

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Jul 2009]

From UniProt:

Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.

From UniProt:

A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of mental retardation and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5.

Cytogenetic Location: Xq22.1, which is the long (q) arm of the X chromosome at position 22.1

Molecular Location: base pairs 101,832,112 to 101,857,577 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Xq22.1, which is the long (q) arm of the X chromosome at position 22.1