NT5E gene

5'-nucleotidase ecto

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

From UniProt:

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.

From NCBI Gene:

  • Calcification of joints and arteries

From UniProt:

Calcification of joints and arteries (CALJA): A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands. [MIM:211800]

Cytogenetic Location: 6q14.3, which is the long (q) arm of chromosome 6 at position 14.3

Molecular Location: base pairs 85,449,584 to 85,495,791 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6q14.3, which is the long (q) arm of chromosome 6 at position 14.3
  • CALJA
  • CD73
  • E5NT
  • eN
  • eNT
  • NT
  • NT5
  • NTE