NRIP1 gene

nuclear receptor interacting protein 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

From UniProt:

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.

From NCBI Gene:

  • CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT 3

Cytogenetic Location: 21q11.2-q21.1, which is the long (q) arm of chromosome 21 between positions 11.2 and 21.1

Molecular Location: base pairs 14,961,235 to 15,065,903 on chromosome 21 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 21q11.2-q21.1, which is the long (q) arm of chromosome 21 between positions 11.2 and 21.1
  • CAKUT3
  • RIP140