NRIP1 gene

nuclear receptor interacting protein 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

From UniProt:

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549).

From NCBI Gene:

  • CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT 3

From UniProt:

Congenital anomalies of kidney and urinary tract 3 (CAKUT3): A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children. CAKUT3 inheritance is autosomal dominant. [MIM:618270]

Cytogenetic Location: 21q11.2-q21.1, which is the long (q) arm of chromosome 21 between positions 11.2 and 21.1

Molecular Location: base pairs 14,961,235 to 15,065,903 on chromosome 21 (Homo sapiens Updated Annotation Release 109.20190607, GRCh38.p13) (NCBI)

Cytogenetic Location: 21q11.2-q21.1, which is the long (q) arm of chromosome 21 between positions 11.2 and 21.1
  • CAKUT3
  • RIP140