NR4A2

nuclear receptor subfamily 4 group A member 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

From UniProt:

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.

Cytogenetic Location: 2q22-q23, which is the long (q) arm of chromosome 2 between positions 22 and 23

Molecular Location: base pairs 156,324,432 to 156,334,683 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q22-q23, which is the long (q) arm of chromosome 2 between positions 22 and 23
  • HZF-3
  • NOT
  • NURR1
  • RNR1
  • TINUR