NPAS3 gene

neuronal PAS domain protein 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

From UniProt:

May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.

From UniProt:

A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13).

Cytogenetic Location: 14q13.1, which is the long (q) arm of chromosome 14 at position 13.1

Molecular Location: base pairs 32,934,785 to 33,804,176 on chromosome 14 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 14q13.1, which is the long (q) arm of chromosome 14 at position 13.1
  • bHLHe12
  • MOP6
  • PASD6