NOS3 gene

nitric oxide synthase 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

From UniProt:

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.

From NCBI Gene:

  • Ischemic stroke
  • Alzheimer's disease
  • Preeclampsia/eclampsia 1
  • Essential hypertension

From UniProt:

Variation in NOS3 seem to be associated with susceptibility to coronary spasm.

Cytogenetic Location: 7q36.1, which is the long (q) arm of chromosome 7 at position 36.1

Molecular Location: base pairs 150,991,056 to 151,014,599 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q36.1, which is the long (q) arm of chromosome 7 at position 36.1
  • ECNOS
  • eNOS