NFKBIL1 gene

NFKB inhibitor like 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

From UniProt:

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.

From NCBI Gene:

  • Rheumatoid arthritis

From UniProt:

Rheumatoid arthritis (RA): An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. [MIM:180300]

Cytogenetic Location: 6p21.3, which is the short (p) arm of chromosome 6 at position 21.3

Molecular Location: base pairs 31,546,851 to 31,558,829 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6p21.3, which is the short (p) arm of chromosome 6 at position 21.3
  • IKBL
  • LST1
  • NFKBIL