NDUFS6 gene

NADH:ubiquinone oxidoreductase subunit S6

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]

From UniProt:

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Cytogenetic Location: 5p15.33, which is the short (p) arm of chromosome 5 at position 15.33

Molecular Location: base pairs 1,801,382 to 1,816,051 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5p15.33, which is the short (p) arm of chromosome 5 at position 15.33
  • CI-13kA
  • CI-13kD-A
  • CI13KDA